College Football Best Bets (9/26/25)

Author: Dylan Lieck | September 26, 2025 | 11:48 A.M. CST

Best Bets:

Virginia +7 vs. Florida State:

Florida State is playing their first true road game of the season, and this is a completely different spot than what they faced week 1 against Bama as a huge underdog. They had nothing to lose. Now they are a big favorite going on the road to a team that’s hungry for a signature win. Additionally, FSU is currently ranked #8 in the country, and they have #2 Miami coming to town next week. In all likelihood, College Gameday will be in Tallahassee for that game, with 1st place in the ACC on the line. Virginia has a prolific offense, and is more than capable of keeping up with FSU if they put up points here. I think this is a spot FSU easily could overlook this Virginia team, and the line really indicates that’s the case. I expected to see 9 or 10 here and we’ve gotten below 7 in some spots. Let’s take the 7 with UVA and I think they are a live dog. 

Arizona State -2.5 vs. TCU:

Look, this number is just too short considering what we know about each team. ASU really should’ve beat Mississippi State a couple weeks ago, but lost on essentially a hail mary. They beat Baylor on the road last week, and their defense was impressive in that showing, holding Baylor’s offense to just 357 total yards. That was an offense averaging 517 yards per game, and over 40 PPG. They scored just 24 in that matchup. Additionally, TCU has faced an incredibly weak schedule. In fact, of all the teams that they beat so far this season, NONE of them have a single win over a Power 4 opponent. We know Arizona State is a solid football team. We know TCU is a decent football team. I made this 4.5 and we’re at home in primetime on a Friday night, with the better coach, and the better QB. I’ll lay less than a FG in this spot easily. Give me ASU all day and lay the 2.5. 

Both Plays:2-Stars